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Secondly, cereblon ligands have desirable physicochemical properties, including low molecular weight, lipophilicity, solubility, chemical and metabolic stability and the absence of pan-assay interference compound (PAINS) warnings 60

6.2 Advantages of nanoparticle-based antioxidant delivery systems Organismal antioxidant delivery systems have recently attracted significant attention as potential tools for the improvement of the therapeutic index of antioxidants particularly in the setting of cancer therapy [297, 298]

Major producers of ROS are mitochondrial cytochrome P-450 reactions, peroxisomal fatty acid metabolism and NADPH oxidase activity [4]

Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility

Increased formation of ROS in mitochondria is a typical phenomenon in diabetic patients with cardiovascular diseases, typically with left ventricular hypertrophy and diastolic dysfunction (Jeong et al